A hypothesis of couplet molecules and couplet cells in gastric function and an association with Helicobacter pylori

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A hypothesis of couplet molecules and couplet cells in gastric function and an association with Helicobacter pylori

BACKGROUND Gastrin, from G-cells, and histamine, from enterochromaffin-like (ECL) cells, are two of the hormones that regulate gastric activity. DISCUSSION It is proposed that the G-cells and the ECL cells are coupled by the couplet molecules gastrin and histamine and by a prior asymmetrical cell division. The gastrin (from G-cells) stimulates the ECL cells to produce and secrete histamine wh...

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All cells require glutamine as a nitrogen donor as well as an energy source for cell-specific functions. Understanding how glutamine utilization is metered to these demands is fundamental to basic cell processes as well as to therapeutic manipulation of regulatory mechanisms. The regulatory role of the glutamine/glutamate couplet in cellular function is illustrated for acid-base homeostasis and...

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Pathogenic interactions between Helicobacter pylori adhesion protein HopQ and human cell surface adhesion molecules CEACAMs in gastric epithelial cells

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ژورنال

عنوان ژورنال: BMC Gastroenterology

سال: 2016

ISSN: 1471-230X

DOI: 10.1186/s12876-016-0429-0